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The Official Scientific Journal of Delhi Ophthalmological Society
Tacrolimus for Ophthalmic Use: An Update

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Sana Ilias Tinwala, Himanshu Shekhar, Sandeep Gupta, Rajesh Sinha, Jeewan S Titiyal
Dr. R.P.Centre for Ophthalmic Sciences, AIIMS, New Delhi- 110029
Corresponding Author:
Dr. Rajesh Sinha
E-mail : sinharaj1@gmail.com
Published Online: 25-SEP-2013
DOI: http://dx.doi.org/10.7869/djo.2012.72
Abstract
Tacrolimus, a macrolide isolated from a strain of Streptomyces, is an immunosuppressant and is used in cases of organ transplantation. It has a mechanism of action similar to that of cyclosporine. It is a lipophilic molecule which blocks the early phase of T-cell activation, thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription. It is also inhibits the release of histamine from mast cells and impairs prostaglandin synthesis. Tacrolimus has shown to be effective in the treatment of immune-mediated diseases such as corneal graft rejection, ocular inflammation, ocular pemphigoid, and uveitis. In this article, we have tried to update the uses of tacrolimus in ophthalmology.
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