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The Official Scientific Journal of Delhi Ophthalmological Society
Clinical Profile and Evaluation of Topical Voriconazole for Management of Fungal Corneal Ulcer in North Western Rajasthan
Kalpna Jain, Jyoti Garhwal, Taruna Swami
Department of Ophthalmology, S.P. Medical College, Bikaner, Rajesthan,India
Corresponding Author:
Kalpna Jain 
MS
Professor,
Department of Ophthalmology, 
S.P. Medical College, Bikaner, India 
Email id: kalpnadaga@gmail.com
Published Online: 30-JUL-2018
DOI: http://dx.doi.org/10.7869/djo.374
Abstract
Aim:- Fungal keratitis is a suppurative and sight-threatening infection of the cornea that sometimes leads to loss of the eye. The study was done to know the efficacy of topical voriconazole in the management of fungal keratitis and prevalent species of fungal corneal ulcer in North Western Rajasthan.
Materials and Methods:- It was a prospective cohort study at a tertiary care center. Fifty patients of fungal corneal ulcer were included in study of either age or sex. All patients were treated with topical voriconazole and response was noted. 
Results:- 60% patients were males and 40% females. Agricultural workers were most commonly affected and the most common cause of injury was vegetative matter (40%). Aspergillus was the most common fungal species (46%). Hypopyon was present in 25 patients. Hypopyon was completely disappeared with topical voriconazole by first week in 18 patients. Improvement in BCVA statistically significant. The mean duration of healing was 5.5 weeks after treatment with topical voriconazole. 
Conclusion:- Ophthalmic mycosis is emerging as a major cause of visual morbidity and can be life-threatening. Voriconazole eye drops appear to be effective and safe when used for the treatment of fungal keratitis. 
Keywords : mycosis, voriconazole, corneal ulcer
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