Delhi Journal of Ophthalmology

Recalcitrant Candidal Corneal Ulcer- A Therapeutic Challenge

Bibek Kumar, N. Z. Farooqui 
Department of Ophthalmology, Deen Dayal Upadhaya Hospital, New Delhi, India

Editor-in-Chief, Delhi Journal of Ophthalmology, Dr R.P.Centre, AIIMS.

Corresponding Author:

Bibek Kumar MBBS, DNB
Post Graduate
Department of Ophthalmology, 
Deen Dayal Upadhaya Hospital, New Delhi, India
Email Id:

Received: 26-AUG-2017 Accepted: 27-OCT-2017 Published Online: 03-MAR-2018

We are hereby presenting a case of recalcitrant fungal corneal ulcer caused by Candida Albicans which did not respond to conventional treatment methods of fungal corneal ulcer ie oral and topical antifungals. The fungal keratitis responded to intrastromal Amphotericin B; thereby highlighting the importance of newer treatment modalities in management of recalcitrant fungal keratitis, e.g. intrastromal and intracameral antifungals. The keratitis started to heal rapidly after the first intrastromal injection of Amphotericin B, and healed completely after three intrastromal injections administered at fortnightly intervals; with residual corneal scarring and vascularization.

Keywords :fungal keratitis, Candida albicans, intrastromal Amphotericin B