Delhi Journal of Ophthalmology

Central Retinal Vein Occlusion in young with Hyperhomocysteinemia - A Case Report and Review of Literature

Ifsa Sami, Reena Sharma, Ahmad Husain, Ravi Ranjan
Department of Ophthalmology, UP University of Medical Sciences, Saifai, Uttar Pradesh, India

Editor-in-Chief, Delhi Journal of Ophthalmology, Dr R.P.Centre, AIIMS.

Corresponding Author:

Reena Sharma MD, DNB
Department of Ophthalmology,
UP University of Medical Sciences,
Saifai,Etawah - 206001,
Uttar Pradesh, India
Email id:

Received: 18-DEC-2018 Accepted: 22-JAN-2019 Published Online: 05-MAY-2019

We present a case of unilateral non-ischemic CRVO in a 22 year male without hypertension, diabetes and open angle glaucoma. Laboratory tests including complete coagulation profile and thrombotic workup were negative, except for raised serum homocysteine level(23.03 µmol/L). The patient was given vitamin supplements for 8 weeks to control homocysteine levels and a single intravitreal bevacizumab injection was given to treat macular edema. The vision and macular thickness improved to normal at 8 weeks, with no recurrence or new cardiovascular complications over a follow-up of one year. We also reviewed the literature and found hyperhomocysteinemia to be a important risk factor for CRVO in the young, and vitamin supplements help in quicker recovery and can prevent recurrence.

Keywords :Venous occlusions, Fundus, Homocysteine, Vitamin