Delhi Journal of Ophthalmology

Mitomycin C: An effective adjunct in the treatment of Ocular Surface Squamous Neoplasia

Neha Verma1, Qamar Jawaid2
1Department of Ophthalmology, Sardar Patel Hospital, Gorakhpur, U.P., India
2Department of Ophthalmology, Sant Parmanand Hospital, Civil Lines, New Delhi, India

Editor-in-Chief, Delhi Journal of Ophthalmology, Dr R.P.Centre, AIIMS.

Corresponding Author:

Qamar Jawaid MBBS, DOMS
436, Civil lines, Sardar Patel Hospital,
Chhatra Sangh Bhawan, Gorakhpur, UP - 273001
Email id:

Received: 12-MAR-2019 Accepted: 30-JUL-2019 Published Online: 27-DEC-2019

A 40 year old female patient presented with a mass in the right eye, foreign body sensation and redness in the right eye for 6 months. Examination revealed a mass in the interpalpebral area,located in the superonasal quadrant, involving the bulbar conjunctiva and cornea. The mass was papillomatous, having a strawberry appearance,with multiple feeder vessels and was sharply demarcated. Visual acuity in the right eye was 6/6p, with full range of ocular movements. The left eye with a visual acuity of 6/6p was normal. AS-OCT performed revealed hyper-reflectivity and a thickened epithelium in the right eye. Histopathological examination confirmed it to be an infiltrating squamous cell carcinoma with moderate differentiation. The lesion was subjected to a wide excision together with intra-operative Mitomycin C (MMC) used in a concentration of 0.04%. Two 1 week courses of topical MMC 0.04% were given post-operatively. The patient was examined at 6 monthly intervals and no recurrence has been observed till third follow-up.

Conclusion: Mitomycin –C is an effective adjuvant in the management of OSSN.

Keywords :Ocular surface squamous neoplasia, Paillomatous, Mitomycin-C, Recurrence

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