Delhi Journal of Ophthalmology

Neoadjuvant Topical Mitomycin C for an Extensive Ocular Surface Squamous Neoplasia

Vaibhav Kumar Jain1,2, Jaya Kaushik3, Savita Agarwal4
1Department of Ophthalmology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India 
2Department of Ophthalmology, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India
3Department of Ophthalmology, Armed Forces Medical College, Pune, Maharashtra, India
4Department of Histopathology, Uttar Pradesh University of Medical Sciences, Saifai Etawah, Uttar Pradesh, India

Editor-in-Chief, Delhi Journal of Ophthalmology, Dr R.P.Centre, AIIMS.

Corresponding Author:

Vaibhav Kumar Jain 
Department of Ophthalmology
Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow-226014,
Uttar Pradesh, India
Email id:

Received: 17-NOV-2018 Accepted: 16-JUL-2019 Published Online: 27-FEB-2020

A sixty-five-year old male presented with an enlarging mass over the ocular surface involving nasal area of conjunctiva, superior and inferior fornix and covering the corneal surface obscuring pupil barring a temporal island of cornea. On the basis of clinical features and impression cytology, the diagnosis of ocular surface squamous neoplasia (OSSN) was made and patient was given neoadjuvant chemotherapy in the form of topical mitomycin C (0.04%) for 6 cycles. Excision biopsy with cryotherapy and amniotic membrane transplantation was performed. At the last follow-up, patient showed no clinical evidence of OSSN.

Keywords :Ocular surface squamous neoplasia (OSSN); mitomycin C (MMC); neoadjuvant chemotherapy; chemoreduction