Delhi Journal of Ophthalmology

Rhino-Orbital Mucormycosis and Aspergillosis in A Child With Thalassemia Major on Deferoxamine Therapy

Siddharth Madan, Sarita Beri, Arunabha Chakravarti, Rajesh Jain, Rahul Maheshwari
Department of Ophthalmology, Lady Hardinge Medical college and Associated Hospitals, University of Delhi, New Delhi, India

Editor-in-Chief, Delhi Journal of Ophthalmology, Dr R.P.Centre, AIIMS.


Corresponding Author:

Siddharth Madan
MS, DNB, FICO, Assistant Professor
Department of Ophthalmology 
Lady Hardinge Medical College, University of Delhi, New Delhi, India
Email: drsiddharthmadan@gmail.com


Received: 04-DEC-2019 Accepted: 07-JAN-2020 Published Online: 12-MAR-2021
DOI: https://dx.doi.org/10.7869/djo.634

Abstract
Rhino-orbital mucormycosis and aspergillosis is a rare potentially fatal opportunistic infection caused by saprophytic fungi. Mucormycosis is described almost exclusively in patients with compromised immune systems or metabolic abnormalities like poorly controlled diabetes. Iron overload states predispose to invasive mucormycosis. Coexistance of mucor and aspergillus is rarely observed and no case has been reported in a child with thalassemia major on deferoxamine therapy. Our patient developed unilateral blindness secondary to invasive fungal infection causing orbital cellulitis. Her journey over seven years of treatment and rehabilitation is described. 

Keywords :Rhino-Orbital Mucormycosis, Aspergillosis, Thalassemia Major, Deferoxamine